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PNU 74654 | Wnt pathway blocker

CAS:
113906-27-7
Catalog Number:
10-4519
Activity:
Wnt pathway blocker
Chemical Name:
2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
Molecular Weight:
320.35
Molecular Formula:
C19H16N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50 = 450 nM) between β-catenin and T cell factor 4 (Tcf4).

References/Citations:

1) Trosset et al. (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins, 64 60

PNU 74654 | Wnt pathway blocker is also available in the Cellular Metabolism Library.
CAS:
113906-27-7
Catalog Number:
10-4519
Activity:
Wnt pathway blocker
Chemical Name:
2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
Molecular Weight:
320.35
Molecular Formula:
C19H16N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee. Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

PNU 74654 | Wnt pathway blocker

can be purchased within the Cellular Metabolism Library with like chemicals.
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50 = 450 nM) between β-catenin and T cell factor 4 (Tcf4).

References/Citations:

1) Trosset et al. (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins, 64 60

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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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