Immunology

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ADC warheads

Adenosine A2A

Preladenant | Potent and selective adenosine A2A antagonist

CAS:

377727-87-2

Catalog Number:

10-4102

Chemical Name:

4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^2,6]dodeca-1(9),2,4,7,11-pentaen-7-amine

Alternate Name:

SCH 420814

Molecular Weight:

503.57

Molecular Formula:

C₂₉H₂₉N₉O₃

Solubility:

Soluble in DMSO (up to 5 mg/ml with warming).

Physical Properties:

Beige solid

Purity:

>98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Shipping Code:

CPI-444 | Adenosine A2A receptor antagonist

CAS:

1202402-40-1

Catalog Number:

10-4101

Activity:

Adenosine A2A receptor antagonist

Chemical Name:

7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine

Alternate Name:

Ciforadenant

Molecular Weight:

407.43

Molecular Formula:

C₂₀H₂₁N₇O₃

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Beige solid

Purity:

98% by HPLC

NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Cancer immunotherapy

BX795 | Dual TBK1/IKKε inhibitor – enhances lentiviral transduction efficiency

CAS:

702675-74-9

Catalog Number:

10-4677

Activity:

Dual inhibitor of TBK1/IKKε

Chemical Names:

N-[3-[[5-Iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide

Molecular Weight:

591.47

Molecular Formula:

C₂₃H₂₆IN₇O₂S

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>97% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Ganetespib | HSP90 inhibitor

CAS:

888216-25-9

Catalog Number:

10-4474

Activity:

HSP90 inhibitor

Chemical Name:

3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one;

Molecular Weight:

364.40

Molecular Formula:

C₂₀H₂₀N₄O₃

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

>98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

URMC-099 | MLK3 inhibitor

CAS:

1229582-33-5

Catalog Number:

10-4012

Activity:

MLK3 inhibitor

Chemical Names:

3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Molecular Weight:

421.54

Molecular Formula:

C₂₇H₂₇N₅

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Cytokines

Sotrastaurin

CAS:

425637-18-9

Catalog Number:

10-4350

Molecular Weight:

438.48

Locostatin | RKIP/Raf-1 kinase disruptor

CAS:

133812-16-5

Catalog Number:

10-5381

Activity:

RKIP/Raf-1 kinase disruptor

Chemical Names:

(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005

Molecular Weight:

245.28

Molecular Formula:

C₁₄H₁₅O₃

Solubility:

Soluble in DMSO (60 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Methotrexate | Dihydrofolate reductase inhibitor

CAS:

133073-73-1

Catalog Number:

10-1260

Activity:

Dihydrofolate reductase inhibitor

Chemical Names:

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740

Molecular Weight:

683.63

Molecular Formula:

C₂₀H₂₂N₈O₅·XH₂O

Solubility:

Soluble in DMSO (45 mg/ml)

Physical Properties:

Yellow solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Glucocorticoid receptors

Dexamethasone | Apoptosis inducing glucocorticoid

CAS:

50-02-2

Catalog Number:

10-1134

Activity:

Apoptosis inducing glucocorticoid

Chemical Name:

(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Molecular Weight:

392.46

Molecular Formula:

C₂₂H₂₉FO₅

Solubility:

Soluble in DMSO (up to 40 mg/ml).

Physical Properties:

White solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months

Shipping Code:

Histamine

Tranilast | Antiallergy agent

CAS:

53902-12-8

Catalog Number:

10-2234

Activity:

NFκB inhibitor

Alternate Names:

Rizaben

Chemical Name:

N-(3′,4′-Dimethoxycinnamoyl)anthranilic acid

Molecular Weight:

327.34

Molecular Formula:

C₁₈H₁₇NO₅

Solubility:

Soluble in DMSO (up to 30 mg/ml).

Physical Properties:

Pale yellow solid

Purity:

98% by TLC
NMR (Conforrms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Astemizole | hERG channel blocker

CAS:

68844-77-9

Catalog Number:

10-1064

Activity:

hERG channel blocker

Chemical Name:

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

Molecular Weight:

457.58

Molecular Formula:

C₂₈H₃₁FN₄O

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

99% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

IDO

NLG919 | IDO pathway inhibitor

CAS:

1402836-58-1

Catalog Number:

10-4564

Activity:

IDO pathway inhibitor

Chemical Name:

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

Molecular Weight:

282.39

Molecular Formula:

C₁₈H₂₂N₂O

Solubility:

Soluble in DMSO (up to 15 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Epacadostat | IDO1 inhibitor

CAS:

1204669-58-8

Catalog Number:

10-4499

Activity:

IDO1 inhibitor/ Cancer immunotherapy enhancer

Chemical Name:

N-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide

Alternate Name:

INCB024360

Molecular Weight:

438.23

Molecular Formula:

C₁₁H₁₃BrFN₇O₄S

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

PF-06840003 | IDO1 inhibitor

CAS:

198474-05-4

Catalog Number:

10-4498

Activity:

IDO1 inhibitor/Cancer immunotherapy enhancer

Chemical Name:

3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione

Alternate Name:

EOS200271

Molecular Weight:

232.21

Molecular Formula:

C₁₂H₉FN₂O₂

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Immunosuppressants

Fludarabine | DNA biosynthesis inhibitor

CAS:

21679-14-1

Catalog Number:

10-5047

Activity:

DNA synthesis inhibitor

Chemical Names:

9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218

Molecular Weight:

285.23

Molecular Formula:

C₁₀H₁₂FN₅O₄

Solubility:

Soluble in DMSO (30 mg/ml)

Physical Properties:

White solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Methotrexate | Dihydrofolate reductase inhibitor

CAS:

133073-73-1

Catalog Number:

10-1260

Activity:

Dihydrofolate reductase inhibitor

Chemical Names:

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740

Molecular Weight:

683.63

Molecular Formula:

C₂₀H₂₂N₈O₅·XH₂O

Solubility:

Soluble in DMSO (45 mg/ml)

Physical Properties:

Yellow solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Gliotoxin | Immunomodulator

CAS:

67-99-2

Catalog Number:

10-2076

Activity:

Immunomodulator

Chemical Names:

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; Aspergillin

Molecular Weight:

326.39

Molecular Formula:

C₁₃H₁₄N₂O₄S₂

Solubility:

Soluble in DMSO (up to 15 mg/ml)

Physical Properties:
White lyophilized solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Kinases

BX795 | Dual TBK1/IKKε inhibitor – enhances lentiviral transduction efficiency

CAS:

702675-74-9

Catalog Number:

10-4677

Activity:

Dual inhibitor of TBK1/IKKε

Chemical Names:

N-[3-[[5-Iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide

Molecular Weight:

591.47

Molecular Formula:

C₂₃H₂₆IN₇O₂S

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>97% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

PLX5622 | Highly selective CSF1R inhibitor

CAS:

1303420-67-8

Catalog Number:

10-4726

Activity:

Highly selective CSF1R inhibitor

Chemical Names:

6-Fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-yl)methyl]pyridine-2-amine

Molecular Weight:

395.41

Molecular Formula:

C₂₁H₁₉F₂N₅O

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Pale yellow solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

GSK2982772 | RIP1 inhibitor

CAS:

1622848-92-3

Catalog Number:

10-4792

Activity:

RIP1 kinase inhibitor

Chemical Names:

(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-traizole-3-carboxamide; GSK772

Molecular Weight:

377.40

Molecular Formula:

C₂₀H₁₉N₅O₃

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Leukotriene receptors

Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist

CAS:

103177-37-3

Catalog Number:

10-2441

Activity:

Leukotriene CysLT1 antagonist / GRP17 antagonist

Chemical Name:

N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami

Alternate Names:

ONO-1078

Molecular Weight:

481.51

Molecular Formula:

C₂₇H₂₃N₅O₄

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

White solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Zafirlukast | HSP70 inhibitor and leukotriene antagonist

CAS:

107753-78-6

Catalog Number:

10-1100

Activity:

Hsp70 inhibitor

Alternate Names:

ICI-204219

Molecular Weight:

575.69

Molecular Formula:

C₃₁H₃₃N₃O₆S

Solubility:

Soluble in DMSO (up to 10 mg/ml).

Physical Properties:

White or pink solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

MK-571 | Cys LT1 antagonist

CAS:

115104-28-4

Catalog Number:

10-1039

Activity:

Cys LT1 antagonist

Alternate Names:

L-660711

Chemical Name:

5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid

Molecular Weight:

515.09

Molecular Formula:

C₂₆H₂₇ClN₂O₃S₂

Solubility:

Soluble in DMSO (up to 50 mg/ml).

Physical Properties:

Yellow solid

Purity:

95% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

Lipoxygenase

Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells

CAS:

491-67-8

Catalog Number:

10-2773

Activity:

Inhibitor of protein tyrosine kinase in leukemia (CEM cells)

Chemical Name:

5,6,7-Trihydroxyflavone

Molecular Weight:

270.24

Molecular Formula:

C₁₅H₁₀O₅

Physical Properties:

Yellow or yellow-green solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

Shipping Code:

Zileuton | 5-LO inhibitor

CAS:

111406-87-2

Catalog Number:

10-1098

Activity:

5-LO inhibitor

Chemical Name:

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Molecular Weight:

236.29

Molecular Formula:

C₁₁H12N₂O₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

>98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

MK-886 | FLAP inhibitor

CAS:

118414-82-7

Catalog Number:

10-1040

Activity:

FLAP inhibitor

Alternate Names:

L-663,536

Chemical Name:

3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid

Molecular Weight:

472.08

Molecular Formula:

C₂₇H₃₄ClNO₂S

Solubility:

Soluble in DMSO (up to 40 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Shipping Code:

NF-kB

Tryptanthrin | Immunomodulator/IDO2 inhibitor

CAS:

13220-57-0

Catalog Number:

10-2228

Activity:

Immunomodulator; IDO2 inhibitor

Chemical Name:

Indolo(2,1-b)quinazoline-6,12-dione

Alternate Names:

NSC 349447; Couroupitine A

Molecular Weight:

248.24

Molecular Formula:

C₁₅H₈N₂O₂

Solubility:

Soluble in DMSO (up to 30 mg/ml)

Physical Properties:

Yellow solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Rocaglamide | TNFalpha inhibitor

CAS:

84573-16-0

Catalog Number:

10-2484

Activity:

TNFalpha inhibitor

Molecular Weight:

505.57

Molecular Formula:

C₂₉H₃₁NO₇

Solubility:

Soluble in DMSO or Ethanol

Physical Properties:

White solid supplied as a thin film on vial.

Purity:

97% by HPLC

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.

Shipping Code:

Triptolide | Immunosuppressant

CAS:

38748-32-2

Catalog Number:

10-2631

Activity:

Immunsuppressant

Chemical Name:

(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one

Alternate Names:

PG490

Molecular Weight:

360.40

Molecular Formula:

C₂₀H₂₄O₆

Solubility:

Soluble in DMSO (up to 7 mg/ml)

Physical Properties:

Tan solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

P2X/P2Y

Pattern recognition receptors

Loxoribine | TLR7 agonist

CAS:

121288-39-9

Catalog Number:

10-3780

Activity:

TLR7 agonist

Chemical Name:

7-Allyl-7,8-dihydro-8-oxoguanosine

Alternate Name:

RWJ-21757

Molecular Weight:

339.30

Molecular Formula:

C₁₃H₁₇N₅O₆

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

96% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Allopregnanolone | GABA-A positive allosteric modulator

CAS:

516-54-1

Catalog Number:

10-3489

Activity:

GABA-A positive allosteric modulator

Chemical Name:

(3α,5α)-3-Hydroxy-pregnan-20-one

Alternate Name:

(3α,5α)-Tetrahydroprogesterone; 3-OH-DHP

Molecular Weight:

318.49

Molecular Formula:

C₂₁H₃₄O₂

Solubility:

Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)

Physical Properties:

White or off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20° (des.)

Stability:

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Shipping Code:

Imiquimod | TLR7 Agonist

CAS:

99011-02-6

Catalog Number:

10-4230

Alternate Name:

R837

Activity:

TLR7 agonist

Chemical Name:

1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine

Molecular Weight:

240.30

Molecular Formula:

C₁₄H₁₆N₄

Solubility:

Soluble in DMSO (2 mg/ml with warming)

Physical Properties:

White solid

Purity:

>98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Prostanoid receptors & prostaglandins

Grapiprant | EP4 Receptor antagonist

CAS:

415903-37-6

Catalog Number:

10-4006

Activity:

EP4 Receptor antagonist

Chemical Name:

1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea

Alternate Names:

CJ-023423; ARY-007

Molecular Weight:

491.61

Molecular Formula:

C₂₆H₂₉N₅O₃S

Solubility:

Soluble in DMSO (up to at least 10 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Prostaglandin E2 | Prostaglandin E (EP) receptor agonist

CAS:

363-24-6

Catalog Number:

10-1358

Activity:

Prostaglandin E (EP) receptor agonist

Alternate Names:

Dinoprost

Chemical Name:

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid

Molecular Weight:

352.47

Molecular Formula:

C₂₀H₃₂O₅

Solubility:

Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).

Physical Properties:

White solid

Purity:

>98% by TLC

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

Blue Ice

Zileuton | 5-LO inhibitor

CAS:

111406-87-2

Catalog Number:

10-1098

Activity:

5-LO inhibitor

Chemical Name:

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Molecular Weight:

236.29

Molecular Formula:

C₁₁H12N₂O₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

>98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

RORγt

SR0987 |RORγt agonist

CAS:

303126-97-8

Catalog Number:

10-4008

Activity:

RORγt Agonist/Cancer immunotherapy enhancer

Chemical Name:

2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide

Molecular Weight:

397.70

Molecular Formula:

C₁₆H₁₀F₆NO₂

Solubility:

Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

STING

SR-717 | STING agonist

CAS:

2375421-09-1

Catalog Number:

10-4850

Activity:

STING agonist

Chemical Names:

Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

Molecular Weight:

381.27

Molecular Formula:

C₁₅H₈F₂N₅O₃·Li

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.

Shipping Code:

RU.521 | cGAS Inhibitor

CAS:

2262452-06-0

Catalog Number:

10-4140

Activity:

cGAS Inhibitor

Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:

415.23

Molecular Formula:

C₁₉H₁₂Cl₂N₄O₃

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white to pale pink solid

Purity:

>98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

CPI-455 | Lysine demethylase KDM5 inhibitor

CAS:

1628208-23-0

Catalog Number:

10-4035

Activity:

Lysine demethylase KDM5 inhibitor

Chemical Name:

7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Molecular Weight:

278.32

Molecular Formula:

C₁₆H₁₄N₄O

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

TGF-β

Other Immunology

Sesamin | Anti-inflammatory natural product

CAS:

607-80-7

Catalog Number:

10-2512

Activity:

Anti-inflammatory natural product

Chemical Names:

5-[(3S,3aR,6S,6aR)-3-(1,3-Benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxole

Molecular Weight:

354.36

Molecular Formula:

C₂₀H₂₈O₆

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

White solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Laquinimod | Immunomodulator

CAS:

248281-84-7

Catalog Number:

10-4971

Activity:

Immunomodulator

Chemical Names:

5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide

Alternate Name:

ABR-215062

Molecular Weight:

356.81

Molecular Formula:

C₁₉H₁₇ClN₂O₃

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor

CAS:

142273-20-9

Catalog Number:

10-3028

Activity:

GSK-3ß/CDK/KLF4 inhibitor

Chemical Names:

9-Bromo-7,12-dihydro-indolo[3,2-d]benzazepine-6(5H)-one; NSC 664704

Molecular Weight:

327.18

Molecular Formula:

C₁₆H₁₁BrN₂O

Solubility:

Soluble in DMSO (35 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Immunology

ADC warheads

Adenosine A2A

Cancer immunotherapy

Cytokines

Glucocorticoid receptors

Histamine

IDO

Immunosuppressants

Kinases

Leukotriene receptors

Lipoxygenase

NF-kB

P2X/P2Y

Pattern recognition receptors

Prostanoid receptors & prostaglandins

RORγt

STING

TGF-β

Other Immunology

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21